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. 2015 Jan 21;15:11. doi: 10.1186/s12885-015-1006-6

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© Savage; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Spermatogenesis and cancer development. The normal and malignant development of testicular germ cells. The normal progression from the primordial germ cell to the production of sperm is shown in the upper pathway. Testicular germ cell tumours develop via CIS from arrested gonocytes that have an impaired mitosis/meiosis switch. Spermatocytic seminoma the malignancy arising from normal pre-meiotic spermatogonia is characteristically chemotherapy resistant.