Table 2.
Logistic regression analysis of HCV spontaneous clearance on local African ancestry for the three most significant regions. The top association within the simple model using an unadjusted logistic regression on local ancestry estimates is denoted simple. The extended label is the top ten associations in that same region, using the extended model of logistic regression on local ancestry estimates, adjusting for HIV status and genotype.
| Chromosomal Region | Analysis | Chromosomal Position | Local Ancestry Odds Ratio | Local Ancestry P-Value |
|---|---|---|---|---|
| 20p12.1 | Simple | 8306421–8370369 | 1.7949 | 8.6821E-04 |
| Extended | 8567519 | 2.0934 | 1.5217E-04 | |
| 8397222 | 1.9052 | 5.7424E-04 | ||
| 8324256 | 1.9190 | 5.7846E-04 | ||
| 8340373 | 1.8762 | 6.3315E-04 | ||
| 8564915 | 2.0477 | 6.6330E-04 | ||
| 8601707 | 2.0531 | 7.4682E-04 | ||
| 8386087 | 1.8501 | 7.9500E-04 | ||
| 8488087 | 1.9291 | 8.1494E-04 | ||
| 8355437 | 1.8593 | 8.1561E-04 | ||
| 8269583 | 1.8185 | 8.3978E-04 | ||
| 20p12.3 | Simple | 13078275–13115148 | 1.7989 | 8.8622E-04 |
| Extended | 13080648 | 2.0676 | 1.6933E-04 | |
| 13199299 | 1.9789 | 2.5846E-04 | ||
| 13082281 | 2.0037 | 3.0541E-04 | ||
| 13892158 | 2.0377 | 3.0996E-04 | ||
| 13111323 | 1.9468 | 3.2714E-04 | ||
| 13095232 | 1.9134 | 3.3491E-04 | ||
| 13281689 | 1.9508 | 3.4468E-04 | ||
| 13112699 | 1.9134 | 3.7582E-04 | ||
| 13260252 | 1.9390 | 4.0612E-04 | ||
| 12898678 | 1.9159 | 4.7388E-04 | ||
| 15q24 | Simple | 76462575–76678692 | 1.8723 | 3.1932E-05 |
| Extended | 77241542 | 2.2330 | 2.2593E-05 | |
| 76678692 | 2.2585 | 2.5100E-05 | ||
| 76772062 | 2.2240 | 2.5778E-05 | ||
| 76490547 | 2.1550 | 3.5743E-05 | ||
| 76930805 | 2.1271 | 4.1500E-05 | ||
| 77176491 | 2.1353 | 5.8441E-05 | ||
| 76521770 | 2.1241 | 6.1589E-05 | ||
| 76965922 | 2.1166 | 6.6862E-05 | ||
| 77087785 | 2.0784 | 6.9310E-05 | ||
| 76470755 | 2.0311 | 7.7342E-05 |