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Overlap of the structures of COX-1 and COX-2 at EI state. The carbon atoms are colored green in COX-1, while cyan in COX-2. Contributions from some important residues to stabilization the transition state are also labeled in red for COX-1 (in kcal/mol), and in blue for COX-2. The negative value indicates that the residue helps decrease the activation barrier, whereas the positive one indicates that the residue would deter the reaction.
