Table 2.
Echocardiographic Measurements of Mice Injected With Tamoxifen for 1 Week
| Basal | Tamoxifen 1 Week | |||
|---|---|---|---|---|
| WT | QL | WT | QL | |
| LVEDD, mm | 3.31±0.05 | 3.55±0.08 | 3.62±0.05 | 3.74±0.07 |
| LVESD, mm | 1.68±0.03 | 1.74±0.07 | 1.69±0.03 | 2.56±0.07* |
| PWT, mm | 0.75±0.02 | 0.74±0.03 | 0.71±0.02 | 0.83±0.04 |
| FS, % | 49.1±0.9 | 50.7±1.54 | 50.6±0.93 | 31.8±1.89* |
| HR, bpm | 486.2±25.2 | 464.3±9.6 | 447.0±8.9 | 333.5±40.0* |
Values are mean±SEM. Serial echocardiographic examinations were done on 3 WT and 3 QL mice at the 2 treatment stages (Basal and Tamoxifen 1 week). WT indicates wild‐type; LVEDD, left ventricular end‐diastolic diameter; LVESD, left ventricular end‐systolic diameter; PWT, posterior wall thickness; FS, fractional shortening; HR, heart rates; bpm, beats per minute.
*
P<0.01; compared with WT‐tamoxifen.