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. 2014 Jun 10;3(3):e000670. doi: 10.1161/JAHA.113.000670

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© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 1. — TSP1‐CD47 signaling is up‐regulated in LVHF. Western immunoblot analysis of protein expression (A and B) and mRNA transcript (C and D) levels of TSP1 and CD47 left ventricle samples from wild‐type (WT) and CD47 (^−/−) null mice pre‐ and 4 weeks post‐TAC. Data are presented as the mean (±SEM; n=3 to 7 animals/group). *=statistically significant difference (P<0.05), compared to control and WT and WT TAC. LVHF indicates left ventricular heart failure; TAC, transverse aortic constriction; TSP1, thrombospondin 1.