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. 2014 Jun 25;3(3):e000790. doi: 10.1161/JAHA.114.000790

Figure 3.

Figure 3.

The intracellular lifetime of water (τic), a measure of cardiomyocyte diameter, increased significantly in the mice treated with l‐NAME, compared to l‐NAME+spironolactone, consistent with the histological appearance of cardiomyocyte hypertrophy. At baseline there was no significantly difference in τic between controls, l‐NAME, and l‐NAME+spironolactone groups. The τic data for the control group are from a previous study, using the same experimental protocol. At follow‐up, τic in the l‐NAME+spironolactone group was not significantly different from controls (P=0.34). l‐NAME indicates Nω–nitro‐l‐arginine‐methyl‐ester.