Table 8.

Integrated Discrimination Improvement and Net Reclassification Improvement by Adding the TDI e' and E/e' to a Model Including Covariables

	Integrated Discrimination Improvement			Net Reclassification Improvement
	IDI (%)	CI (%)	P Value	NRI (%)	CI (%)	P Value
Cardiovascular events
TDI e'	3.05	0.89 to 5.21	0.006	54.2	28.1 to 80.3	<0.0001
E/e'	−0.084	−1.14 to 0.97	0.87	0.69	−27.0 to 25.6	0.96
Cardiac events
TDI e'	5.03	1.57 to 8.48	0.004	64.0	32.9 to 95.0	<0.0001
E/e'	0.48	−2.31 to 3.27	0.74	7.30	−24.5 to 39.1	0.65

The basic model includes as covariables sex, age, body mass index, systolic blood pressure, serum cholesterol, smoking, diabetes mellitus, and history of cardiac disease (see Table 3). The integrated discrimination improvement (IDI) is the difference between the discrimination slopes of basic models and basic models extended with a predictor variable. The discrimination slope is the difference in predicted probabilities (%) between subjects with and without event. The net reclassification improvements (NRI) reflect the improvement in discriminative power by adding a predictor variable to a Cox model already including important covariables. TDI indicates tissue Doppler imaging.