Table 1.
Baseline Characteristics for HIV‐Positive Patients Who Experienced CVD Events According to Severity
| No Event* | Fatal CVD* | Nonfatal CVD* | P Value* | |
|---|---|---|---|---|
| Baseline characteristics, n | 9476 | 74 | 214 | |
| Age (y), median (IQR) | 42 (36 to 48) | 48 (41 to 54) | 49 (42 to 54) | 0.76 |
| Sex (% female) | 22 | 14 | 8 | 0.21 |
| Race (% black) | 19 | 23 | 16 | 0.20 |
| BMI (kg/m2), median (IQR) | 24.3 (22.1 to 27.0) | 24.0 (22.1 to 27.0) | 24.3 (22.1 to 27.1) | 0.58 |
| CD4+ cell count, (cells/mm3) median (IQR) | 487 (367 to 669) | 409 (331 to 644) | 469 (356 to 633) | 0.63 |
| HIV‐RNA<500 copies/mL, % | 77 | 74 | 77 | 0.64 |
| Earlier AIDS event, % | 26 | 39 | 29 | 0.10 |
| IL‐6, (pg/mL) median (IQR) | 1.8 (1.2 to 2.8) | 3.1 (1.9 to 4.5) | 2.3 (1.5 to 3.5) | 0.01* |
| % highest tertile (<1.88)* | 20 | 45 | 28 | |
| % middle tertile (1.88≤×<3.14)* | 27 | 31 | 36 | |
| % lowest tertile (≥3.14)* | 52 | 24 | 36 | 0.02* |
| D‐dimer, (μg/mL) median (IQR) | 0.24 (0.15 to 0.37) | 0.35 (0.24 to 0.61) | 0.27 (0.17 to 0.45) | 0.006* |
| % highest tertile (<0.22) | 21 | 45 | 29 | |
| % middle tertile (0.22≤×< 0.41) | 31 | 32 | 34 | |
| % lowest tertile (≥0.41) | 47 | 23 | 37 | 0.03* |
| hsCRP, (μg/mL) median (IQR) | 1.6 (0.7 to 3.6) | 3.1 (1.1. to 7.5) | 2.2 (1.1 to 5.6) | 0.26* |
| % highest tertile (<1.55) | 21 | 39 | 31 | |
| % middle tertile (1.55≤×<4.17) | 29 | 32 | 34 | |
| % lowest tertile (≥4.17) | 50 | 28 | 35 | 0.49* |
| IL‐6 and D‐dimer score median (IQR) | −0.02 (−0.60 to 0.61) | 0.85 (0.20 to 1.36) | 0.30 (−0.20 to 0.89) | 0.003 |
| % highest tertile (<1.04) | 19 | 51 | 27 | |
| % middle tertile (1.04≤×<1.75) | 28 | 26 | 36 | |
| % lowest tertile (≥1.75) | 53 | 23 | 37 | 0.001* |
BMI indicates body mass index; CVD, cardiovascular disease; hsCRP, high‐sensitivity C‐reactive protein; IQR, interquartile range.
No event measurements noted for completeness.
Deaths attributed to CVD and unwitnessed deaths not resulting from violence, suicide, or drug abuse that were not proceeded by a nonfatal event or deaths within 28 days of the nonfatal CVD event.
Nonfatal myocardial infarction, coronary artery disease requiring surgery, or nonfatal stroke for participants that survived at least 28 days.
From a univariate logistic model comparing fatal and nonfatal CVD events (n=288).
P values reported based on log2‐transformed biomarker measurement.
P value based on 2 df chi‐square test.
Tertiles were defined using all of the patients in the 3 studies that experienced a fatal or nonfatal CVD event.