Table 3.
Unadjusted and Covariate Adjusted* Odds Ratios for Fatal CVD* (Versus Nonfatal CVD*) According to Tertile and Associated With a Doubling of Each Biomarker or 1‐Unit Increase of IL‐6 and D‐Dimer Score
| Biomarker | Lowest Tertile | Middle Tertile | Highest Tertile | OR Associated With Doubling of Biomarker | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | OR | 95% CI | P Value | OR | 95% CI | P Value | Omnibus P Value* | OR | 95% CI | P Value | |
| IL‐6, pg/mL | |||||||||||
| Univariate | 1.0 | 1.32 | (0.66 to 2.64) | 0.44 | 2.46 | (1.25 to 4.87) | 0.01 | 0.02 | 1.39 | (1.07 to 1.79) | 0.01 |
| Adjusted | 1.0 | 1.41 | (0.69 to 2.88) | 0.34 | 2.62 | (1.26 to 5.46) | 0.01 | 0.02 | 1.41 | (1.07 to 1.86) | 0.01 |
| D‐dimer (μg/mL) | |||||||||||
| Univariate | 1.0 | 1.63 | (0.80 to 3.33) | 0.18 | 2.47 | (1.25 to 4.85) | 0.009 | 0.03 | 1.40 | (1.10 to 1.78) | 0.007 |
| Adjusted | 1.0 | 1.74 | (0.80 to 3.75) | 0.16 | 2.70 | (1.27 to 5.75) | 0.01 | 0.05 | 1.45 | (1.10 to 1.92) | 0.008 |
| hsCRP (μg/mL) | |||||||||||
| Univariate | 1.0 | 1.17 | (0.60 to 2.29) | 0.65 | 1.49 | (0.77 to 2.88) | 0.24 | 0.49 | 1.09 | (0.93 to 1.28) | 0.31 |
| Adjusted | 1.0 | 1.17 | (0.59 to 2.33) | 0.65 | 1.55 | (0.78 to 3.10) | 0.21 | 0.39 | 1.10 | (0.93 to 1.30) | 0.29 |
| IL‐6 and D‐dimer score | |||||||||||
| Univariate | 1.0 | 1.15 | (0.56 to 2.38) | 0.71 | 3.07 | (1.57 to 6.00) | 0.001 | 0.001 | 1.51 | (1.15 to 1.97) | 0.003 |
| Adjusted | 1.0 | 1.20 | (0.57 to 2.54) | 0.64 | 3.67 | (1.74 to 7.72) | <0.001 | <0.001 | 1.58 | (1.17 to 2.13) | 0.003 |
hsCRP indicates high‐sensitivity C‐reactive protein; OR, odds ratio.
*
Covariates include: study indicators, log‐transformed time to event, age, gender, race, body mass index, HIV‐RNA, baseline CD4+ cell count, and earlier AIDS at baseline.
*
Number of fatal CVD events=74.
*
Number of nonfatal CVD events=214.
*
Based on 2 df chi‐square test.