Table 4.
Unadjusted and Covariate Adjusted* Hazard Ratios for All‐Cause Mortality After Nonfatal CVD* (n=214) Events Associated With a Doubling of Biomarker or 1‐Unit Increase in IL‐6/D‐Dimer Score
| Biomarker | Median (IQR) | Univariate | Adjusted | |||||
|---|---|---|---|---|---|---|---|---|
| Deaths (n=23) | Survivors (n=191) | HR | 95% CI | P Value | HR | 95% CI | P Value | |
| IL‐6, pg/mL | 3.1 (2.3 to 6.2) | 2.2 (1.5 to 3.2) | 1.72 | (1.28 to 2.31) | <0.001 | 1.85 | (1.25 to 2.72) | 0.002 |
| D‐dimer, μg/mL | 0.47 (0.29 to 0.59) | 0.27 (0.17 to 0.42) | 1.73 | (1.27 to 2.36) | <0.001 | 1.76 | (1.17 to 2.66) | 0.007 |
| hsCRP, μg/mL | 5.3 (2.6 to 7.5) | 2.0 (1.0 to 4.9) | 1.44 | (1.15 to 1.80) | 0.001 | 1.39 | (1.08 to 1.78) | 0.01 |
| IL‐6 and D‐dimer score | 0.94 (0.37 to 1.57) | 0.18 (−0.25 to 0.72) | 1.88 | (1.39 to 2.55) | <0.001 | 2.01 | (1.35 to 3.01) | <0.001 |
CVD indicates cardiovascular disease; hsCRP, high‐sensitivity C‐reactive protein; HR, hazard ratio.
*
Covariates include: study indicators, log‐transformed time to event, age, gender, race, body mass index, HIV‐RNA at baseline and proximal to nonfatal CVD event, CD4+ cell count at baseline and proximal to nonfatal CVD event, and earlier AIDS at baseline.
*
Number of deaths after a nonfatal CVD event=23, including deaths attributed to CVD and unwitnessed deaths not resulting from violence, suicide, or drug abuse.