Table 5.

Vasculature Mechanics of All Groups of Mice Were Assessed

Vascular Mechanics at 150 mm Hg	Lean	Lean Myostatin−/−	db/db	db/db Myostatin−/−
Inner lumen diameter, mm	214.28±7.26	206.97±5.53	259.37±9.10###	229.20±9.51###***
Wall thickness, mm	7.22±0.67	7.98±0.99	9.13±0.99	8.74±1.70
Wall: lumen ratio	0.07±0.01	0.08±0.01	0.07±0.01	0.08±0.02
Cross‐section area, μm2	5016.20±514.84	5477.93±761.84	7786.36±894.38##	6528.36±1275.30***

Data are given as the mean±SEM. n=8. db/db myostatin^−/− indicates mice lacking both myostatin and leptin receptor; db/db, obese leptin receptor‐deficient mice heterozygous for myostastin; lean myostatin^−/−, myostatin‐null mice heterozygous for leptin receptors; lean, lean dual heterozygotes.

***P<0.001, lean versus lean myostatin^−/− or db/db versus db/db myostatin^−/−. ^##P<0.01; ^###P<0.001, lean versus db/db or lean myostatin^−/− versus db/db myostatin^−/−.