Table 8.

The Likelihood of Severe Aortic Stenosis, Severe Aortic Stenosis due to Calcific Degeneration of Tricuspid Aortic Valve, and Severe Aortic Stenosis due to Bicuspid Valve Disease Given Each Categorical Risk Factor

Characteristic		Total	SAS	CDT	BVD
Sex	Male	115 326	1.00%	0.55%	0.31%
	Female	144 312	0.68%	0.44%	0.14%
	OR* for males		1.47*	1.25*	2.22*
Race	African American	36 681	0.29%	0.18%	0.04%
	Caucasian	222 976	0.91%	0.54%	0.24%
	OR* for African Americans		0.32*	0.33*	0.17*
Diabetes mellitus	Yes	40 581	1.98%	1.41%	0.35%
	No	136 812	0.97%	0.51%	0.30%
	OR* ratio for diabetes		2.06*	2.79*	1.17
Hypertension	Yes	111 354	1.60%	1.04%	0.36%
	No	81 862	0.44%	0.13%	0.19%
	OR* for hypertension		3.68*	8.07*	1.90*
Coronary artery disease	Yes	19 392	4.99%	3.32%	0.98%
	No	206 343	0.57%	0.30%	0.18%
	OR* for coronary artery disease		9.16*	11.41*	5.49*
Statin use	Yes	70 592	1.89%	1.24%	0.43%
	No	189 065	0.42%	0.21%	0.13%
	OR* for statin use		4.57*	5.97*	3.32*
Overall percent			0.82%	0.49%	0.21%

The overall and etiology‐specific probability of severe aortic stenosis based on presence of each risk factor or demographic is shown. Among patient with a given risk factor classification, the proportion of patients with severe aortic stenosis, severe aortic stenosis due to calcific degeneration of a native tricuspid valve, and severe aortic stenosis due to a bicuspid aortic valve are shown with the overall odds ratio for the difference. Group with higher probability of severe aortic stenosis included males, Caucasians, those with hypertension, diabetes mellitus, or coronary artery disease, and those prescribed statins. BVD indicates proportion with severe aortic stenosis due to bicuspid valve disease; CDT, proportion with severe aortic stenosis due to calcific degeneration of tricuspid aortic valve; SAS, proportion with severe aortic stenosis.

^*OR: crude odd ratio for developing severe aortic stenosis given a demographic or presence of a risk factor unadjusted for any other factors.

^*P<0.0001.