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. 2014 Jun 3;3(3):e000884. doi: 10.1161/JAHA.114.000884

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© 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 1. — Conserved region (CNS) and its relationship with TG and CAD‐associated SNP identified by GWAS. A, The position of the SNP identified in this study are shown in red relative to the CAD/TG‐associated SNP (black). TRIBAL exons are numbered. B, CNS region and its conservation. PhastCons (UCSC Genome Browser) analysis of CNS and surrounding region, focusing on vertebrates. SNPs are indicated at bottom. Of common SNPs, only rs2001844 (underlined in red) is located within the ≈500‐bp CNS region. The TG associated SNP rs2001945 is boxed in black. C, TRIB1 and the CAD‐associated SNPs occupy distinct LD blocks. LD plot generated by HaploView (version 4.2) highlighting the lack of linkage between SNPs associated with the TRIB1 coding region and the SNPs associated with CAD. Analysis was performed using the 1000 Genome indexed SNPs spanning chromosome 8: 126447308 to 126486409. Blocks shown (black triangles) were defined by CIs. CAD indicates coronary artery disease; CNS, conserved region; GWAS, genome‐wide association studies; LD, linkage disequilibrium; SNP, single nucleotide polymorphism; TG, triglycerides.