Table 4.
Multivariable Adjusted Odds Ratios for Increasing Baseline Quartiles of Fibrinogen, sICAM‐1, and hsCRP and Incident Stroke
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P‐Trend | |
|---|---|---|---|---|---|
| Fibrinogen | |||||
| mg/dL | <322 | 322 to 368 | 369 to 427 | >427 | |
| OR* | 1.00 | 0.99 | 1.14 | 1.18 | 0.63 |
| 95% CI | Referent | 0.46 to 2.13 | 0.54 to 2.40 | 0.51 to 2.72 | |
| P | Referent | 0.98 | 0.73 | 0.70 | |
| N | 30 | 26 | 41 | 41 | |
| sICAM‐1 | |||||
| ng/mL | <318 | 318 to 359 | 360 to 415 | >415 | |
| OR* | 1.00 | 1.27 | 1.51 | 1.58 | 0.21 |
| 95% CI | Referent | 0.62 to 2.61 | 0.69 to 3.29 | 0.78 to 3.21 | |
| P | Referent | 0.51 | 0.29 | 0.64 | |
| N | 29 | 32 | 34 | 43 | |
| hsCRP | |||||
| mg/L | <1.2 | 1.2 to 2.3 | 2.4 to 4.6 | >4.6 | |
| OR* | 1.00 | 1.40 | 1.48 | 3.42 | 0.007 |
| 95% CI | Referent | 0.64 to 3.12 | 0.59 to 3.67 | 1.35 to 8.71 | |
| P | Referent | 0.40 | 0.40 | 0.01 | |
| N | 20 | 28 | 35 | 60 | |
Data are from the case‐control portion of the study. LDL‐C indicates low‐density lipoprotein cholesterol; HDL‐C, high‐density lipoprotein cholesterol; HRT, hormone replacement therapy; hsCRP, high‐sensitivity C‐reactive protein; sICAM‐1, soluble intercellular adhesion molecule type 1.
*
Odds ratios (OR) were matched for age, smoking, and HRT and adjusted for systolic blood pressure (mm Hg), HDL‐C (mg/dL), LDL‐C (mg/dL), body mass index (kg/m2), diabetes, and parental history of myocardial infarction before age 60 years.