Table 2.
Baseline Biomarker Levels According to the Development of Paroxysmal and Nonparoxysmal AF Among 25 007 Women Who Donated Blood Samples
| Baseline Biomarker | No AF (N=24 200) | Paroxysmal AF (N=530) | P Value* | Nonparoxysmal AF (N=277) | P Value* | P Value* |
|---|---|---|---|---|---|---|
| HbA1c | 0.06 | <0.001 | 0.002 | |||
| ≤4.84% | 25.4 | 23.0 | 15.2 | |||
| 4.84% to ≤5.00% | 24.8 | 22.2 | 21.7 | |||
| >5.00% to 5.19% | 25.2 | 28.3 | 27.4 | |||
| >5.19% | 24.6 | 26.6 | 35.7 | |||
| GFR <60 mL/min per 1.73 m2, % | 5.1 | 6.4 | 0.16 | 9.4 | 0.001 | 0.13 |
| Inflammatory score, % | <0.001 | <0.001 | ||||
| 0 | 39.4 | 27.5 | 25.3 | |||
| 1 | 31.8 | 32.6 | 33.7 | 0.70 | ||
| 2 | 19.6 | 25.4 | 27.1 | |||
| 3 | 9.2 | 14.4 | 13.9 | |||
| Lipids, median (IQR) | ||||||
| HDL, mg/dL | 52.1 (43.3 to 62.5) | 51.4 (42.3 to 61.9) | 0.30 | 52.3 (43.4 to 62.8) | 0.94 | 0.61 |
| LDL, mg/dL | 121.2 (100.3 to 144.1) | 118.9 (99.5 to 144.0) | 0.61 | 128.3 (105.2 to 149.2) | 0.01 | 0.02 |
| Triglycerides, mg/dL | 117.0 (83.0 to 173.0) | 127.0 (92.0 to 178.0) | 0.001 | 118.0 (86.0 to 181.0) | 0.12 | 0.43 |
AF indicates atrial fibrillation; HbA1c, hemoglobin A1c; GFR, glomerular filtration rate; IQR, interquartile range; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein.
*
P value comparing women with paroxysmal AF with women with no AF.
*
P value comparing women with nonparoxysmal AF with women with no AF.
*
P value comparing women with paroxysmal AF and women with nonparoxysmal AF.