Table 2.
Least‐Squares Means* (Standard Error) of Cardiovascular Risk Markers by Levels of Fetuin‐A Among Controls,* the Nurses' Health Study
| Quintiles of Fetuin‐A (μg/mL) | P for Trend | |||||
|---|---|---|---|---|---|---|
| 1 (Lowest) | 2 | 3 | 4 | 5 (Highest) | ||
| Median, range | 326.1 (83.0 to 368.6) | 398.8 (369.0 to 423.2) | 448.4 (425.1 to 472.0) | 494.4 (472.2 to 536.3) | 590.3 (536.8 to 1589.7) | |
| Biomarkers | ||||||
| TC, mg/dL | 222.8 (4.4) | 234.9 (4.5) | 226.2 (4.4) | 227.0 (4.4) | 230.1 (4.4) | 0.55 |
| LDL‐C, mg/dL | 133.3 (4.0) | 145.9 (4.1) | 136.7 (4.0) | 135.3 (4.0) | 137.3 (4.0) | 0.96 |
| HDL‐C, mg/dL | 60.4 (1.6) | 59.3 (1.6) | 59.6 (1.6) | 60.8 (1.6) | 56.7 (1.6) | 0.19 |
| Total:HDL‐C ratio | 3.9 (0.1) | 4.3 (0.1) | 4.0 (0.1) | 4.0 (0.1) | 4.4 (0.1) | 0.02 |
| TG mg/dL | 111.5 (6.2) | 112.7 (6.3) | 110.0 (6.2) | 115.1 (6.3) | 144.7 (6.5) | 0.0004 |
| hsCRP, mg/dL | 0.29 (0.04) | 0.24 (0.04) | 0.30 (0.04) | 0.34 (0.04) | 0.35 (0.04) | 0.19 |
| HbA1c, % | 5.5 (0.1) | 5.4 (0.1) | 5.6 (0.1) | 5.3 (0.1) | 5.6 (0.1) | 0.47 |
| Adiponectin, μg/mL | 9.8 (0.4) | 9.2 (0.4) | 9.4 (0.4) | 9.2 (0.4) | 8.7 (0.4) | 0.06 |
| eGFR, mL/min per 1.73 m2 | 86.9 (1.5) | 83.7 (1.5) | 84.1 (1.5) | 82.3 (1.5) | 83.9 (1.5) | 0.16 |
eGFR indicates estimated glomerular filtration rate; HbA1c, hemoglobin A1c; HDL‐C, high‐density lipoprotein cholesterol; hsCRP, high‐sensitivity C‐reactive protein; LDL‐C, low‐density lipoprotein cholesterol; TC, total cholesterol; TG, triacylglycerol.
Adjusted for age at blood draw (year), body mass index (kg/m2), smoking status (current smoker, past smoker, nonsmoker), postmenopausal status (yes, no), hormone use (current user, past user, and nonuser), alcohol use (nondrinker, <5.0, 5.0 to 14.9, 15.0 to 29.9, and ≥30.0 g/day), and fasting status (yes, no).
N=463 for TC, HDL‐C, TC:HDL‐C ratio, and eGFR, n=459 for LDL‐C and hsCRP, n=439 for TG, n=461 for adiponectin, and n=396 for HbA1c.