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. 2014 Jun 19;3(3):e000976. doi: 10.1161/JAHA.114.000976

Table 2.

List of Genes With Differential Expression and Methylation

Gene Name ACGT Chr Location Region % DM Fold Change Function
AI661453 Chr17 47582589 Genebody 74%** −2.02 Cellular component
Acaca Chr11 84088161 Genebody 73%** −2.01 Long chain fatty acid biogenesis
Abi1 Chr2 22839713 Genebody 73%** −2.03 Negative regulation of cell growth and transformation, Ras signaling, Cardiovascular and placental development
Aff2 ChrX 66755393 Genebody 70%* −2.02 RNA‐binding protein
Atf6 Chr1 172773438 Genebody 79%* −2.00 Unfolded protein response during ER stress
Arhgef12 Chr9 42820787 Genebody 74%* −2.02 Acts as a guanine nucleotide exchange factor
Ank Chr15 27482616 Genebody 59%** −2.03 Osteoblast/osteoclast differentiation, hypoxia responsive/regulated by Hif1α
Ank Chr15 27513341 Genebody 78%** −2.03
Ank Chr15 27427229 Genebody 21%* −2.03
Ank Chr15 27430132 Genebody 52% −2.03
Atrnl1 Chr19 58000444 Genebody 84%** −4.06 G‐protein coupled receptor signaling, may regulate energy homeostasis
Atrnl1 Chr19 57683177 Promoter 29% −4.06
Atrnl1 Chr19 58054451 Genebody 35% −4.06
Atxn1 Chr13 45770455 Genebody 67%** −2.02 Chromatin binding factor that represses Notch signaling.
Brdt Chr5 107807029 Genebody 75%** −2.00 Chromocenter organization, Spermatogenesis
Cacna2d3 Chr14 30485237 Genebody 74%** −2.03 Voltage‐gated calcium channel activity, Regulated by promoter methylation, contractility of ventricular myocytes
Cacna2d3 Chr14 30303225 Genebody 22% −2.03
Cd180 Chr13 103491174 Genebody 66%* −2.00 Innate immune response, life/death decision of B‐cells
Cdk14 Chr5 4822015 Genebody 76%** −4.07 Cell cycle regulation
Cdk14 Chr5 5428041 Enhancer 23% −4.07
Casz1 Chr4 148329448 Enhancer 80%** −2.00 Blood vessel development and lumen morphogenesis, differentially methylated in a tissue specific manner
Cdh4 Chr2 179440423 Genebody 75%** −2.01 Calcium dependent cell adhesion, may play a role in retinal development, Regulated by methylation
Cdh4 Chr2 179292446 Genebody 22% −2.01
Cdh4 Chr2 179316146 Genebody 21% −2.01
Cdh4 Chr2 179385054 Genebody 19%* −2.01
Clasp1 Chr1 120296717 Genebody 75% −2.03 Regulation of microtubule dynamics, mitosis
Chrna9 Chr5 66367625 Genebody 71%** −1.94 Ion transport, cochlea hair development
Chrna9 Chr5 66348791 Enhancer 20%** −1.94
Col9a1 Chr1 24203890 Genebody 63%** −2.02 Expressed in developing heart, differentially methylated in cancer
Clasp2 Chr9 113641090 Enhancer 69%** −2.02 Microtubule stabilization, mitosis
Creb1 Chr1 64569233 Enhancer 81%** −2.02 Gene transcription, HIF‐1‐alpha transcription factor network
D6Wsu116e Chr6 116164345 Genebody 76%** −4.05 N/A
Csde1 Chr3 102840451 Genebody 59%** −2.00 RNA binding and transcriptionally coupled mRNA turnover
Disc1 Chr8 127751886 Genebody 78%** −2.02 Multiple roles in embryonic and adult neurogenesis. Associated with schizophrenia
Dach2 ChrX 110423200 Genebody 65%** −2.04 Eye and limb development and sex determination
Dgkb Chr12 38744479 Genebody 73%** −1.88 Brain development
Dnajc11 Chr4 151311759 Genebody 78%** −2.03 Heat shock binding protein
Dlx5 Chr6 6859827 Enhancer 77%* −2.03 Transcriptional activator during bone development, Promotes cell proliferation, osteoblast differentiation. Cell type specific expression regulated by methylation
Dnajc2 Chr5 21291210 Promoter 69%** 2.00 DNA replication
Dlg2 Chr7 99358525 Genebody 60%** −2.00 Regulation of synaptic stability, Chronic pain perception
Eif2ak4 Chr2 118271831 Genebody 86%* −2.01 Hypoxia response
Emilin2 Chr17 71603514 Genebody 78%** −4.05 Extracellular matrix component, regulates methylation in breast cancer
Emilin2 Chr17 71606328 Genebody 74%** −4.05
Fam73a Chr3 151956508 Genebody 81%** −2.01 Integral to membrane
Fam111a Chr19 12661528 Genebody 78%** −2.02 Simian virus 40 (SV40) host range restriction factor
Fbxw7 Chr3 84630582 Genebody 77** −2.00 Mediates ubiquitination and subsequent proteasomal degradation of target proteins including NOTCH1, inactivated by promoter hypermethylation
Fancl Chr11 26311200 Genebody 73%* −2.04 Mediates monoubiquitination, may play a role in primordial germ cell proliferation
Fancl Chr11 26368061 Genebody 96%* −2.04
Fbxw8 Chr5 118558780 Genebody 92%* −2.02 Mediates ubiquitination and subsequent proteasomal degradation of target proteins, placental development
Ftsjd2 Chr17 29820177 Genebody 67%** −2.01 Methyltransferase that mediates mRNA cap1
Fscn1 Chr5 143721993 Promoter 67%* −2.03 Cell migration, motility, adhesion and cellular interactions
Has2 Chr15 56549727 Enhancer 65%* −16.31 Heart valve development
Grik4 Chr9 42754379 Promoter 79%* −2.04 Glutamate receptor in CNS
Invs Chr4 48429137 Genebody 67%** −4.05 Embryonic heart tube left development and right pattern formation
Invs Chr4 48288832 Promoter 24%* −4.05
Il6st Chr13 113256622 Genebody 77%* −2.01 Signal transduction. Plays a role in embryonic development, vascular endothelial growth
Hipk2 Chr6 38796532 Genebody 61%* −2.00 Angiogenesis, marked for degradation by hif1‐a in cancer
Itgb1 Chr8 131241575 Genebody 78%** −2.03 Promotes endothelial cell motility and angiogenesis, Hif1 regulated in wound healing
Itsn1 Chr16 91786820 Genebody 79%* −2.02 Adaptor protein linking endocytic membrane traffic and actin assembly machinery
Isg20 Chr7 86061520 Genebody 62%** 3.97 Viral response
Itga1 Chr13 115765151 Genebody 66%** −2.04 Integrin and Collagen Binding, rapid methylation leading to initiation of megakaryocyte differentiation
Itga1 Chr13 115800600 Genebody 20%** −2.04
Kcne4 Chr1 78770239 Enhancer 77%** 7.87 Potassium voltage channel, cardiac function (cardiomyopathy)
Kif26b Chr1 180479937 Genebody 81%** −2.00 Embryonic kidney development, plays a role in compact adhesion between mesenchymal cells
Klhl2 Chr8 67366115 Genebody 76%* −2.02 Mediate ubiquitination of target proteins, Plays a role in the reorganization of actin cytoskeleton
Ksr1 Chr11 79001767 Enhancer 82%** −2.04 Promotes MEK and RAF phosphorylation and activity
Ksr1 Chr11 78904857 Genebody 20% −2.04
Limk1 Chr5 135156130 Genebody 80%* −2.04 Regulation of actin filament dynamics, cell motility, cell cycle progression and differentiation
Lmf1 Chr17 25771254 Genebody 82%** −2.04 Maturation and transport of lipoprotein lipase through the secretory pathway
Mkrn2 Chr6 115567892 Genebody 62%* 2.01 Neurogenesis
Ncoa7 Chr10 30373619 Genebody 75%** 2.02 Co‐activation of several nuclear receptors
Ncam1 Chr9 49570879 Genebody 61%* 4.06 Neural adhesion, pathological angiogenesis in oxygen induced retinopathy, ventricular wall thickening in hypertension, cardiac protection
Odz3 Chr8 49397492 Genebody 73%** −2.00 Signal transduction, neuronal growth and tumorigenesis
Odz3 Chr8 49336206 Genebody 47%** −2.00
Odz3 Chr8 49341811 Genebody 21% −2.00
Pam Chr1 99716878 Enhancer 79%** 4.07 Heart development and hypoxia response
Pde5a Chr3 122538715 Genebody 79** 2.02 Signal transduction, cardiac muscle contraction and hypertrophy, hypoxia response
Pde11a Chr2 75840713 Genebody 70%* 1.98 Signal transduction, may play a role in vascular smooth muscle proliferation and contraction, cardiac contractility and immune cell activation
Pcgf5 Chr19 36450106 Promoter 71%* 2.02 Maintenance of transcriptional repressive state in development, including that of Hox genes
Pfkfb3 Chr2 11406131 Genebody 78%** 2.03 Induced by Hif1α
Pet112 l Chr3 85403998 Genebody 70%* 2.03 Glutamyl‐tRNA amidotransferase complex, Functions in mitochondria
Pip5k1b Chr19 24602322 Genebody 72%** 4.06 Phosphorylation
Pnkd Chr1 74336698 Genebody 65%** 2.00 Hydrolase activity, Plays an aggregative role in the development of cardiac hypertrophy via NF‐kappa‐B signaling
Pou2f1 Chr1 167866210 Promoter 70%** −2.01 Regulates gene expression in response to stress and metabolic signals
Ppm1 h Chr10 122245574 Genebody 67% 4.05 Phosphatase activity, drug response in cancer, associated with systemic lupus erythematosus
Ppm1 h Chr10 122144175 Genebody 19%** 4.05
Prdm16 Chr4 153999781 Genebody 68%** 2.02 Transcriptional regulation, Functions as a repressor of TGF‐beta signaling
Ppwd1 Chr13 104995653 Genebody 67%** 2.02 Putative peptidylprolyl isomerase, may be involved in pre‐mRNA splicing
Ptn Chr6 36663240 Enhancer 75%** 4.07 Angiogenesis, tumorigenesis, regulation of hematopoietic stem cell self renewal, mammary gland development
Prmt8 Chr6 127665685 Genebody 79%* −2.07 Arginine methyltransferase, embryonic and neural development, regulated by auto‐methylation
Prkca Chr11 108120704 Genebody 86%** 2.00 Regulation of transcription, cell growth, immune response, negative regulation of cell proliferation, apoptosis, differentiation, cardiac hypertrophy and angiogenesis
Ranbp3 Chr17 56833581 Genebody 78%* 2.02 Nuclear export, negative regulator of TGF‐beta signaling through SMAD
Ptpro Chr6 137362114 Genebody 71%** 2.00 Wnt‐protein binding, Candidate tumor suppressor, aberrantly methylated in cancer
Ptpru Chr4 131336827 Genebody 69%** 1.84 Cell proliferation and migration, maintenance of epithelial integrity, neural development and possible megakaryocytopoiesis
Rbfox3 Chr11 118610022 Genebody 65%* 1.97 RNA‐binding, associated with neurocytoma and cerebral artery occlusion
Rhd Chr4 134418089 Promoter 81%** −8.00 Encodes member of Rh blood group proteins
Rbm39 Chr2 155977061 Genebody 75% 4.05 Transcriptional co‐activator for steroid nuclear receptors, involved in pre‐mRNA splicing
Rpia Chr6 70726365 Genebody 67%** 2.02 Carbohydrate metabolism
Robo2 Chr16 74182881 Genebody 72% −2.00 Heart Morphogenesis, linear hear tube formation, neuronal development
Rpn2 Chr2 157147564 Genebody 55%** 2.04 Ribosome binding, Dolichyl‐diphosphooligosaccharide‐protein glycotransferase activity
Rsu1 Chr2 13110936 Genebody 79%** 2.01 Ras signal transduction pathway
Rsu1 Chr2 13153759 Genebody 50%* 2.01
Rufy2 Chr10 62447503 Genebody 65% 2.03 Alzheimer's disease
Sav1 Chr12 71078443 Genebody 76%** 2.03 Transcription, cell proliferation, cell death, cell migration, cell cycle exit, protein degradation and RNA splicing
Slc24a2 Chr4 86672633 Genebody 58%** 2.03 Calcium and potassium transport
Slmap Chr14 27308224 Genebody 79% 4.07 Myoblast fusion
Slco5a1 Chr1 12939917 Genebody 61% −1.97 Transporter activity
Sorbs2 Chr8 46655637 Genebody 79%** 2.02 Cytoskeletal adaptor activity and structural constituent of cytoskeleton
Sorbs2 Chr8 46649975 Genebody 20% 2.02
Stxbp6 Chr12 46076554 Genebody 79%** 1.96 Regulates SNARE complex formation
St8sia5 Chr18 77402859 Enhancer 80%** 2.02 Synthesis of gangliosides
Srsf9 Chr5 115781199 Genebody 73% 2.03 Splicing
Tex9 Chr9 72307706 Genebody 67%** 2.02 —
Tbc1d16 Chr11 119004863 Genebody 64%** 1.99 Rab GTPase activator activity
Tbc1d16 Chr11 119017735 Genebody 76%** 1.99
Taf4a Chr2 179700219 Genebody 72%** 2.01 Basal transcription
Tet2 Chr3 133187569 Genebody 85%** 2.01 DNA demethylation regulating transcription
Tmem38a Chr8 75105110 Genebody 69%** 4.06 Potassium channel activity
Tnrc6a Chr7 130306203 Genebody 73%** 2.02 Gene silencing by RNA and microRNA
Tmem135 Chr7 96306156 Genebody 82%* 2.02 Peroxisome organization
Tmem135 Chr7 96397839 Genebody 29% 2.02
Tubg2 Chr11 101015396 Promoter 19% −2.01 Major constituent of microtubules, structural molecule activity
Vmn1r73 Chr7 12307910 Enhancer 63%** 2.00 —
Wnk1 Chr6 119946851 Genebody 86%** −1.98 Heart development, regulations of cell signaling, survival and proliferations, electrolyte homeostasis, cytoskeletal reorganization and sodium and chloride ion transport
Zbtb20 Chr16 43500263 Genebody 89%** −2.01 Transcription factor involved in hematopoiesis, oncogenesis and immune response
Zbtb20 Chr16 43219787 Enhancer 95% −2.01
Zbtb20 Chr16 43343231 Genebody 98% −2.01
Zbtb20 Chr16 43455368 Genebody 97% −2.01
Wnt6 Chr1 74821915 Genebody 65% −4.35 Tissue development
Zdhhc8 Chr16 18231749 Genebody 72% 4.00 Susceptibility to schizophrenia
Zfp385b Chr2 77445243 Genebody 73%* −2.02 Metal ion, nucleic acid, p53, and zinc ion binding, Apoptotic processes
Zfp385b Chr2 77629407 Genebody 21%* −2.02
Enah Chr1 183952945 Promoter 25% −2.01
Pkd2 Chr5 104885245 Promoter 22% 1.99 Tubular morphogenesis, associated with autosomal dominant polycystic kidney disease
Mylk2 Chr2 152734667 Promoter 20% −1.91 Cardiac function and global muscle contraction
Ppp1r1c Chr2 79544612 Promoter 25% −1.93 Promotes cell cycle progression and increases cell susceptibility to TNF‐induced apoptosis
Spns2 Chr11 72304383 Promoter 59%** −4.03 Migration of myocardial precursors; cardiovascular, immunological and neural development
Elf1 Chr14 79879478 Promoter 31% −4.05 Endothelial transcription factor
Ppp1r3c Chr19 36813263 Promoter 44% −2.01 Glycogen synthase, Regulated by Hif1α
Gucy1a3 Chr3 81943306 Genebody 23%** −2.02 Cardiac function, vascular smooth muscle function
Gucy1a3 Chr3 81993497 Enhancer 23%** −2.02
Ank2 Chr3 126729907 Enhancer 97% −2.01 Expression and targeting of SPTBN1 in neonatal cardiomyocytes and regulation of neonatal cardiomyocyte contraction rate
Sfrp2 Chr3 83534574 Enhancer 30% 8.05 Cell growth and differentiation, Wnt signaling, myogenesis and eye retinal development, methylation of gene is a potential marker for colorectal cancer
Erbb4 Chr1 68142043 Genebody 23% −4.04 Heart development, cardiac muscle differentiation and postnatal cardiomyocyte differentiation, CNS development, neural crest cell migration, gene transcription, cell proliferation, differentiation, migration and apoptosis
Erbb4 Chr1 68846422 Genebody 20% −4.04
Erbb4 Chr1 68938673 Genebody 38% −4.04
Erbb4 Chr1 68954441 Genebody 20% −4.04
Erbb4 Chr1 69128731 Genebody 24% −4.04
Mysm1 Chr4 94660067 Enhancer 28%** −2.00 Histone modification and transcriptional co‐activation
Foxp1 Chr6 98892345 Genebody 19% −2.04 Cardiomyocyte proliferation
Foxp1 Chr6 99008217 Genebody 22%* −2.04
Foxp1 Chr6 99018432 Genebody 34% −2.04
Foxp1 Chr6 99163145 Genebody 20% −2.04
Foxp1 Chr6 99197140 Genebody 23% −2.04
Foxp1 Chr6 99357158 Genebody 22% −2.04
Foxp1 Chr6 99391693 Enhancer 43%* −2.04
Unc5c Chr3 141321392 Genebody 19% −8.07 Cell migration in neural development, axon extension and induction of apoptosis
Unc5c Chr3 141342275 Genebody 26% −8.07
Unc5c Chr3 141359065 Genebody 20% −8.07
Sox5 Chr6 143990289 Genebody 20% −4.01 Embryonic development, cell fate determination, transcriptional regulation
Sox5 Chr6 144141969 Genebody 19% −4.01
Psd3 Chr8 70278799 Genebody 19%* −2.03 Guanine nucleotide exchange factor for ARF6
Psd3 Chr8 70338543 Genebody 96% −2.03
Psd3 Chr8 70459139 Genebody 23%* −2.03
Dock1 Chr7 142059905 Genebody 28% −2.01 Cytoskeletal rearrangements necessary for phagocytosis of apoptotic cells and in cell motility Guanine nucleotide exchange factor
Dock1 Chr7 142061686 Genebody 19% −2.01
Dock1 Chr7 142073658 Genebody 30% −2.01
Dock1 Chr7 142115224 Genebody 24% −2.01
Dock1 Chr7 142136783 Genebody 24% −2.01
Dock1 Chr7 142190260 Genebody 53% −2.01
Wwox Chr8 117142250 Genebody 31% −2.03 Apoptosis, TGFB1 signaling and TGFB1‐mediated cell death. Inhibits Wnt signaling
Wwox Chr8 117354691 Genebody 26% −2.03
Wwox Chr8 117632214 Genebody 22% −2.03
Vegfc Chr8 55148115 Enhancer 21% 2.02 Angiogenesis and endothelial cell growth
Vegfc Chr8 55239360 Genebody 18.5%* 2.02
Vegfc Chr8 55247617 Genebody 22% 2.02
Pard3 Chr8 129591554 Genebody 28%* −2.00 Adaptor protein, asymmetrical cell division and cell polarization, plays a role in epithelial tight junctions
Pard3 Chr8 129640346 Genebody 96%** −2.00
Pard3 Chr8 129830952 Genebody 96% −2.00
Pard3 Chr8 129845627 Genebody 21%** −2.00
Pard3 Chr8 129875488 Genebody 22% −2.00
Pard3 Chr8 129914177 Genebody 24% −2.00
Thsd4 Chr9 59846658 Genebody 19%* −2.00 Attenuates TGFB signaling
Thsd4 Chr9 59968525 Genebody 22% −2.00
Thsd4 Chr9 60041974 Genebody 19%* −2.00
Thsd4 Chr9 60098887 Genebody 96%* −2.00
Rora Chr9 68624882 Genebody 19%** −2.01 Regulated genes involved in lipid metabolism
Rora Chr9 68726640 Genebody 24%** −2.01
Rora Chr9 68865723 Genebody 19% −2.01
Utrn Chr10 12126998 Genebody 20%* 2.02 Anchors cytoskeleton to plasma membrane
Utrn Chr10 12213501 Genebody 20% 2.02
Utrn Chr1012395503 Genebody 19% 2.02
Mef2c Chr13 83687636 Genebody 96% −1.99 Transcription activator controls cardiac morphogenesis and myogenesis, plays a role in vascular development
Mef2c Chr13 83755977 Genebody 30%** −1.99
Mef2c Chr13 83797333 Genebody 25% −1.99
Odz2 Chr11 35940645 Genebody 35%* −1.98 Neural development
Odz2 Chr11 36164904 Genebody 20%* −1.98
Odz2 Chr11 36400641 Genebody 32%** −1.98
Odz2 Chr11 36725324 Genebody 27%** −1.98
Ptprk Chr10 27825617 Genebody 20%* −2.01 Regulation of cell contact and adhesions, tumor invasion/metastasis, Negative regulator of EGFR signaling
Ptprk Chr10 28084547 Genebody 24% −2.01
Ptprk Chr10 28226602 Genebody 24%** −2.01
Enox1 Chr14 77538059 Enhancer 97% −2.00 Oxidoreductase activity, nucleotide binding
Enox1 Chr14 77771534 Genebody 23% −2.00
Enox1 Chr14 77876556 Genebody 20%* −2.00
Enox1 Chr14 77977395 Genebody 20%** −2.00
Zfpm2 Chr15 40787554 Genebody 29% −2.01 Transcription regulator important in heart morphogenesis and coronary vessel development from epicardium
Zfpm2 Chr15 40824705 Genebody 95%** −2.01
Zfpm2 Chr15 40848971 Genebody 19% −2.01
Dach1 Chr14 98263585 Genebody 97%* −1.99 Transcription factor important in organogenesis
Dach1 Chr14 98304412 Genebody 26% −1.99
Dach1 Chr14 98510700 Genebody 96% −1.99
Erc2 Chr14 28475844 Genebody 97% −1.99 Cytomatrix organization at nerve terminal active zones regulating release of neurotransmitters
Erc2 Chr14 28668685 Genebody 30% −1.99
Erc2 Chr14 28822634 Genebody 95% −1.99
Erc2 Chr14 28845440 Genebody 24% −1.99
Vps13b Chr15 35600466 Genebody 23%** −1.99 Protein sorting in post Golgi membrane traffic, may play a role in development and function of the eye, hematological system and the CNS
Vps13b Chr15 35777972 Genebody 19% −1.99
Vps13b Chr15 35817931 Genebody 23%* −1.99
2810403A07Rik Chr3 88506464 Genebody 84% −2.01 RNA binding
Tle4 Chr19 14528880 Genebody 20%* −2.01 Transcriptional co‐repressor of members in Wnt signaling
Tle4 Chr19 14621827 Genebody 24% −2.01
Prkg1 Chr19 30823222 Genebody 19%* −2.02 Regulates cardiac function, smooth muscle contraction, platelet activation and adhesion
Prkg1 Chr19 31528132 Genebody 24% −2.02
Prkg1 Chr19 31595749 Genebody 20% −2.02
Hif1a Chr12 75032797 Genebody 25% −2.00 Hypoxia response, Master transcriptional regulator
Malt1 Chr18 65586771 Promoter 19%* −2.00 NF‐kappaB activation
Igf2r Chr17 12965268 Promoter 44% −2.02 Activation of TGF‐β. Intracellular trafficking of lysosomal enzymes and degradation of IGF2, tumorigenesis, Paternally imprinted
Krtap9‐1 Chr11 99731190 Promoter 27% 8.00 Hair shaft formation
Ccdc40 Chr11 119085948 Promoter 20% −4.03 Motile cilia function. Ciliary dyskinesia type 15
Cftr Chr6 18119186 Promoter 20% −2.00 Chloride channel and enzyme binding, associated with cystic fibrosis
Cftr Chr6 18242079 Genebody 42% −2.00
Pdzd2 Chr15 12315935 Genebody 23% 2.02 Prostate tumorigenesis
Pdzd2 Chr15 12342544 Genebody 27% 2.02
Pdzd2 Chr15 12521967 Promoter 19% 2.02
Elovl2 Chr13 41317598 Promoter 23% −4.04 Atherosclerosis, protein binding and fatty acid elongase activity
Gpr18 Chr14 122316980 Promoter 96% 1.98 Regulation of immune system, bipolar disorder
Rpn1 Chr6 88030514 Promoter 24% −2.01 Dolichyl‐diphosphooligosaccharide‐protein glycotransferase activity
Mosc1 Chr1 186637543 Promoter 19% −4.12 —
Tmem150c Chr5 100589921 Promoter 25% −2.04 —
Shroom3 Chr5 93236380 Promoter 27% −2.01 Regulation of cell shape in neuroepithelium
Calb1 Chr4 15806105 Promoter 24% −1.95 Functions in purkinje cells
Gpr61 Chr3 107962781 Promoter 22%** 8.01 G‐protein coupled receptor signaling
Cd40 Chr2 164871483 Enhancer 96% −2.02 Immune and inflammatory response
Ephx1 Chr1 182951005 Promoter 23% 2.02 Cis‐stilbene‐oxide hydrolase activity, epoxide hydrolase activity. Plays a role in preeclampsia
Arhgap29 Chr3 121628392 Enhancer 96% −2.00 Rho GTPase activator activity, essential role in blood vessel tubulogenesis
Fbxl4 Chr4 22244260 Enhancer 21% −2.02 Cell cycle control
Fbxl4 Chr4 22264607 Enhancer 21% −2.02
Zmat3 Chr3 32233835 Genebody 96%** −1.96 TP53‐dependent growth regulatory pathway and TP53‐mediate apoptosis, inhibits tumor cell growth
Zmat3 Chr3 32278426 Enhancer 22% −1.96
Fam125b Chr2 33790838 Enhancer 23%** −2.03 Vesicular trafficking
Serpinb2 Chr1 109370955 Enhancer 31% −4.08 Serine‐type endopeptidase inhibitor activity
Rims1 Chr1 22615396 Genebody 97%* −2.02 Exocytosis, maintenance of neurotransmitter release and regulation of release during short‐term synaptic plasticity
Rims1 Chr1 22763512 Genebody 96% −2.02
Dst Chr1 34249899 Genebody 20% −2.01 Cytoskeletal linker protein, Regulation of keratinocyte polarity and mobility
Dst Chr1 34315083 Genebody 20% −2.01
Dst Chr1 34322642 Genebody 26% −2.01
Etl4 Chr2 20373784 Genebody 23% 2.00 Intervertebral disk development
Etl4 Chr2 20576360 Genebody 95%* 2.00
Esrrg Chr1 189527991 Genebody 46% −2.00 Transcriptional activator via estrogen response elements
Esrrg Chr1 189976300 Genebody 21%* −2.00
Dnm3 Chr1 163949959 Genebody 22% −1.99 Megakaryocyte development, likely involved in endocytosis
Dnm3 Chr1 164108264 Genebody 40%** −1.99
Rbms1 Chr2 60615270 Genebody 25% −2.02 Cell cycle progression, apoptosis, DNA replication and gene transcription.
Rbms1 Chr2 60789032 Genebody 19% −2.02
Lrba Chr3 86163560 Genebody 23% −2.01 Signal transduction and vesicle trafficking
Lrba Chr3 86267521 Genebody 21% −2.01
Plcb1 Chr2 134819839 Genebody 23% −1.99 Intracellular transduction of extracellular signals
Plcb1 Chr2 135145732 Genebody 25% −1.99
Meis2 Chr2 115688950 Genebody 96% −2.01 Transcriptional regulation
Meis2 Chr2 115750462 Genebody 96% −2.01
Bach2 Chr4 32560314 Genebody 21%* −2.00 Transcriptional regulation
Bach2 Chr4 32629036 Genebody 21% −2.00
Kcnd3 Chr3 105447527 Genebody 16%* −1.84 Smooth muscle contraction, heart rate, insulin secretion, neuronal excitability and cell volume
Fam19a1 Chr6 96068370 Genebody 31% −1.91 Regulators of immune cells and cells of the nervous system
Fam19a1 Chr6 96235296 Genebody 19%** −1.91
Drosha Chr15 12715566 Enhancer 22% −2.03 Cleaves ds‐RNA in micro RNA processing
Drosha Chr15 12817558 Genebody 27% −2.03
Gsk3b Chr16 38062422 Enhancer 20% −2.01 Negative regulator in hormonal control of glucose homeostasis, Wnt signaling and the regulation of transcription factors and microtubules. Regulates NFatc1 expression. Mediates development of insulin resistance
Gsk3b Chr16 38138300 Genebody 20%** −2.01
Gsk3b Chr16 38218276 Genebody 96% −2.01
Pmm2 Chr16 8627532 Enhancer 33% −2.02 Glycoprotein biosynthesis
Osta Chr16 32515415 Enhancer 31% −2.00 Transporter activity
Krt8 Chr15 101867475 Enhancer 23% −4.02 Signal transduction and cellular differentiation
Slc38a4 Chr15 96905406 Enhancer 96% −2.00 Sodium‐dependent amino acid transporter
Slc38a2 Chr15 96516885 Enhancer 20%* −2.03 Supply of maternal nutrients to fetus through placenta, transport of amino acids at blood‐brain barrier
Adra2a Chr19 54118496 Promoter 26% 1.99 Mediates the catecholamine‐induced inhibition of adenylate cyclase

Table provides differentially expressed genes with corresponding differential methylation (DM) sites. Bolded DM values indicate decreased methylation at E14.5 whilst unbolded DM values indicates increased methylation at E14.5.

*Notes P<0.05 in methylation changes and **notes P<0.01 in methylation changes. Gene functions are summarized.