Figure 7.

Catecholaminergic polymorphic ventricular tachycardia calmodulin induces abnormal Ca²⁺ transients. A, Representative Ca²⁺ transients in cardiomyocytes expressing calmodulin‐N54I. B, Loss of entrainment for frequencies ≥1 Hz; for 3 Hz, no entrainment was possible. P<10⁻⁴. C, Representative Ca²⁺ transient displaying alternans at 1 Hz. D, For 1 Hz, all calmodulin‐N54I cardiomyocytes displayed abnormal Ca²⁺‐transient phenotypes; the majority of cells displayed alternans. P<10⁻⁴. WT indicates wild type.