Table 1.
Persistent Current % | n | |
---|---|---|
NaV1.5+apo WT* CaM | 0.3±0.2 | 4 |
NaV1.5+apo CaM‐D130G | 0.2±0.1 | 4 |
NaV1.5+WT CaM | 0.3±0.1 | 5 |
NaV1.5+CaM‐D130G | 0.2±0.1 | 5 |
NaV1.5+CaM‐D96V | 0.2±0.1 | 7 |
NaV1.5+CaM‐F142L | 0.1±0.1 | 4 |
Fetal NaV1.5+apo WT CaM | 0.4±0.1 | 6 |
Fetal NaV1.5+apo CaM‐D130G | 0.6±0.2 | 7 |
Fetal NaV1.5+WT CaM | 0.2±0.1 | 9 |
Fetal NaV1.5+CaM‐D130G | 1.5±0.4*,* | 13 |
Fetal NaV1.5+CaM‐D96V | 0.4±0.1 | 8 |
Fetal NaV1.5+CaM‐F142L | 0.6±0.5 | 8 |
CaM indicates calmodulin; WT, wild type.
apo WT CaM is Apocalmodulin (apo WT CaM is Ca2+‐free CaM; WT refers to the disease‐associated sites identified in the probands2).
P<0.05 compared to fetal NaV1.5+WT CaM.
P<0.05 compared to fetal NaV1.5+WT CaM with 10 μmol/L KN‐93.
Data compared using Kruskal‐Wallis 1‐way ANOVA and Dunn's Test.