Figure 3.

MEMRI was more sensitive for detecting early-stage MB than conventional T2w MRI. Representative examples are shown for wild-type (A, B, E, and F) and Ptch1-CKO mice (C, D, G, and H) scanned with both non-contrast T2w RARE (left panels; A, C, E, and G) and post-contrast T1w MEMRI sequences (right panels; B, D, F, and H). These images show improved tissue contrast in MEMRI compared to RARE images and show higher sensitivity for visualization of tumor tissue (*) using MEMRI (D) compared to RARE (C), especially for detection of early pretumoral lesions with MEMRI (H, arrowheads), which could not be detected with RARE (G). Scale bars, 1 mm.