Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(Left) Crystal structure of [Rh(bpy)2(chrysi)]3+, the first generation metalloinsertor, bound to an AC mismatch in duplex DNA. (Right, top) Chemical structure of [Rh(chrysi)(phen)(DPE)]2+, a later generation metalloinsertor with enhanced selectivity and potency. (Right, bottom) Cell-selective cytotoxicity of [Rh(chrysi)(phen)(DPE)]2+, the complex selectively kills MMR-deficient (red) cells over MMR-proficient (green) cells.
