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. Author manuscript; available in PMC: 2015 Jan 28.
Published in final edited form as: J Neurovirol. 2004 Jun;10(3):141–151. doi: 10.1080/13550280490441103

Figure 2.

Figure 2

Time-lapse digital photomicrographs showing the effects of HIV-1 Tat1-72 or gp120 on striatal neuron survival prior to (Before treatment; left column) and at 72 h following exposure (right column) in vitro (A–F). The effects of Tat or gp120 were additionally assessed in the presence or absence of Z-DEVD-FMK (30 µM) (DEVD) a caspase inhibitor applied 4 hours prior to viral protein exposure. Tat1-72 (100 nM) (B) and gp120 (500 pM) (D) were neurotoxic compared to treatment with media alone (A). However, only gp120 (E), but not Tat (C), induced neuronal losses were significantly attenuated by DEVD. Black arrows represent dying neurons, white arrows show viable neurons; scale bars = 25 µm.

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