Fig. 2.

Knockout of the CatB gene, but not BACE1, in AβPPWT/Lon mice results in improved memory acquisition. AβPPWT/Lon mice (Control), AβPPWT/Lon × CatB KO mice (CatB KO mice), and AβPPWT/Lon × BACE1 KO mice (BACE1 KO mice) were trained in the Morris water maze test on each of 4 consecutive days to learn the location of a submerged, invisible platform in a pool of water. The time that it took the mice to swim to the platform was recorded each day, measured as the latency period (seconds), with shorter latency times indicating better memory acquisition. Latency (secs) is shown as x ± s.e.m. (**, ***Statistically significant, p < 0.05, n = 10 per group).