Table 2.
Summary of gene expression analysis of MF/SS from microarray studies.
| Authors | Platform | Source | Findings |
|---|---|---|---|
| Willers et al (2001) | 588 gene Atlas membrane array | SS cells/skin derived T cell culture | Interferon inhibiting cytokine factor |
| Kari et al (2003) | cDNA filter – 4500 genes | SS PBMC | PLS3, GATA3, JUNB, ITGB1, PRG2, RHOB (ARHB), decreased DPP4, STAT4 and IL1R1 |
| Tracey et al (2003) | cDNA oncochip - 6386 | MF skin | 27 genes – BIRC3, BIRC1, TRAF, TNFR apoptosis regulators, STAT4, CD40L |
| Mao et al (2004) | Affy cDNA HuGenFl (12k) | MF/SS | JUNB and BCL2 increased copy number. Affy showed decreased RASA1, STAT3, STAT4, STAT5A |
| Van Doorn (2004) | Affy U95A | SS | Increased: EPHA4 and TWIST1. Decreased: TGFBR2, MXI1, PRDM2, STAT4, BCL11A |
| Mao et al (2006) | FISH, Affy U133A (13.5k genes) | MF/SS | CCND1/BCL1 increased in some. EB1 loss, CCND2, CCND3 increased |
| Mao et al (2008) | FISH, Affy U133A | SS | JUNB and JUND increased. Phosphorylated MAPK1 (ERK). Increase JUNB copy number |
| Hahtola (2006) | Affy U133A | Skin and blood, CD4 | Th2 cytokine increased in SS, loss of T-bet (TBX21) NKG7 and CCL5 (SCYA5) decreased in SS |
| Booken et al (2008) | AffyU133 Plus2(54k genes) | CD4 | 7 genes significant – CDO1, DNM3, NEDD4L, IGFL2, TNFSF11, KLHDC5. TWIST1 affects DNM3 and CDO1 |
| Kennah et al (2009) | Affy 133Plus2 | Hut78 | HCK, AHI1, BIN1 in transformed MF |
| Wozniak (et al 2009) | cDNA oncochip 6386 | MF skin, PUVA-resistant | NF-kB TCR signalling altered in PUVA resistance. Increased NFKB1, and Th2 signalling. Differences seen in tumour microenvironment |
| Shin et al (2007) | AffyU133A | MF skin | 3 clusters- T cell genes in cluster 1, LOR in cluster 2, FOSL1, SERPINB13 in cluster 3. |
| Litvinov et al (2010) | AffyU133A | MF skin | WIF1 favourable prognosis, IL17F poor prognosis |
| Chong et al (2010) | AffyU133 Plus2 | PBMC, SS | 9/14 memory genes decreased in SS |
| Pomerantz et al (2010) | Illumina Sentrix 24k genes | CD4/CD45RO cells | ZBTB16 increased, IRF3 and IFI35 decreased |
SS, Sezary Syndrome; MF, Mycosis Fungoides; PBMC, peripheral blood mononuclear cells; PUVA, psoralen combined with ultraviolet A.