Table 1. Inhibitory activity of periploside A and analogues against T-lymphocyte proliferation*.
Compound | CC50 (μM) | IC50 (μM) | SI |
---|---|---|---|
Periploside A (1) | 2.10±0.32 | 0.17±0.04 | 12 |
C1′′-epi-periploside A (31) | 1.58±0.19 | 0.41±0.15 | 3.9 |
C1′′′-epi-periploside A (41) | 11.40±3.66 | 1.96±0.43 | 5.8 |
Disaccharide 42 | 12.80±0.52 | 6.20±3.20 | 2.1 |
Disaccharide 43 | 27.70±6.61 | 3.70±2.25 | 7.5 |
*See Supplementary Methods and Supplementary Figs 62 and 63 for details.