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The fatty acid/Zn2+ switch on serum albumin. (A) Overlay of crystal structures of human serum albumin with (gray; Protein Data Bank [PDB] 1BJ5 [26]) and without (green; PDB 1AO6 [61]) myristate (Myr) bound, showing the location of the major Zn2+-binding site. (B) Close-up showing the movement of Zn2+-coordinating residues His247 and Asp249 relative to His67 and Asn99 between the two structures.
