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. 2015 Jan 28;10(1):e0114370. doi: 10.1371/journal.pone.0114370

Figure 1. Signaling pathways in regulation of cell migration and proliferation in response to glucose.

Figure 1

(A) Detailed multi-level action of miR-451 on proliferation-associated signaling pathways. Solid line = experimentally validated results, dashed line = putative results based on a prediction software. (B, C) Proposed role of the miR-451-AMPK-mTOR core control system in the regulation of cell proliferation and migration in response to high and low glucose levels. [6, 18] (CAB39/LKB1/AMPK/MARK) in the AMPK complex, which deactivates suppression of mTOR by the AMPK complex and leads to elevated proliferation and decreased cell polarity and migration. When the glucose level is low, down-regulation of miR-451 results in up-regulation of AMPK activity, which inhibits mTOR, thus leading to reduced proliferation, metabolic adaptation/survival, and increased cell polarity and migration through phosphorylation of MARKs. This also affects the cytoskeleton promoting cell migration for cell migration.