Figure 9. Dynamics of diffusible molecules.

(A-D) Spatial profiles of glucose (G in (A)), chemoattractant (C in (B)), ECM (ρ in (C)), and MMP (P in (D)) at t = 0, 100, 200, 240 h that corresponds to Figs. 8A–8D. Glucose fluxes are provided at BV sites. The chemoattractant was injected at the center of the domain (0.5, 0.5). Domain size = [0, 1]². Glucose is continuously supplied through BVs while chemoattractants diffuse through the domain after strategic injections at the center to attract infiltrative glioma cells. ECM is degraded and undergoes constant remodeling via MMPs secreted by migratory tumor cells toward the center during the localization process.