Table 1. Parameters used in the intracellular miR-451-AMPK-mTOR system.

	Description	Value	Refs
λg	glucose signaling rate	1.0	[41]
λ1	autocatalytic production rate of miR-451	4.0	[41]
λ2	Hill-type coefficient	1.0	[41]
α	Inhibition strength of miR-451 by AMPK complex	1.6	[41]
th M	Threshold of AMPK for proliferation/migration switch	2.0	Estimated
λ3	autocatalytic production rate of AMPK	4.0	[41]
λ4	Hill-type coefficient	1.0	[41]
β	Inhibition strength of AMPK complex by miR-451	1.0	[41]
S 1	Signaling source of AMPK	0.2	[41]
ϵ 1	Scaling factor (slow dynamics) of AMPK complex	0.02	[15, 41, 51, 52]
th A	Threshold of AMPK for proliferation/migration switch	2.0	Estimated
λ5	autocatalytic production rate of mTOR	4.0	Estimated
λ6	Hill-type coefficient of mTOR module	1.0	Estimated
γ	Inhibition strength of mTOR activity by AMPK	1.0	Estimated
S 2	Signaling source of mTOR	1.2	Estimated
ϵ 2	Scaling factor (slow dynamics) of mTOR	0.02	[15, 51, 52], estimated
th R	Threshold of AMPK for proliferation/migration switch	3.0	Estimated