Figure 1.

Demonstration of a partial gene duplication using DOTTER analysis. Part of the adaptin gene (AP1B1) has been duplicated and rearranged 2.8 Mb telomeric on chromosome 22, to leave a structure in which the duplicated exon 6 (ADTB1L1) is followed 3′ by the duplicated exon 1 (ADTB1L2) and there is conservation of the surrounding intron sequences. Genomic sequence accession number and portion of the sequence used is indicated (note AC000026 has been reversed). Gene structures are shown by a black line (introns) and hashed boxes (exons), and an arrow pointing toward the 3′ end of the gene. Within the dot matrix, diagonal lines indicate regions of sequence identity and dashed lines show where exon sequences align.