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. Author manuscript; available in PMC: 2015 Jan 28.
Published in final edited form as: Hypertension. 2012 Sep 10;60(5):1226–1233. doi: 10.1161/HYPERTENSIONAHA.112.197871

Figure 8.

Figure 8

ETS-1 blockade reduces angiotensin II (Ang II)–induced nitrotyrosine formation and NOX4 expression. A, Representative photomicrographs of immunofluorescence for nitrotyrosine. B, Quantitative analysis of the intensity of cortical nitrotyrosine immunofluoroscence from mice infused with Ang II for 4 weeks with and without concomitant infusion of ETS-1 dominant-negative (ETS-1 DN) or ETS-1 mutant (ETS-1-MU) peptide showing significant increase in nitrotyrosine in response to Ang II, which is significantly reduced by ETS-1 DN but not by ETS-1 MU (n=6 per group; *P<0.05 vs control; #P<0.05 vs Ang II). C, NOX4 mRNA expression as assessed by real-time polymerase chain reaction after 2 and 4 weeks of Ang II, which is increased by Ang II and reduced by ETS-1 DN but not by ETS-MU (*P<0.01 vs control; #P<0.01 vs Ang II and Ang II+ETS-1 MU).