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. Author manuscript; available in PMC: 2015 Jan 28.
Published in final edited form as: Stem Cells. 2013 May;31(5):895–905. doi: 10.1002/stem.1323

Figure 4. Cell migration during early reprogramming can lead to clonal dispersal.

Figure 4

A) Time-lapse observation of a colony breaking off from the originating field of view (top row), landing at another site and continuing to develop into a normal colony (bottom row). The colony at the time of breaking away and landing is indicated by the large white arrow. The imaging system captured this event during its scan at 62 hours from the originating field to the landing field following a path as illustrated in Fig S2. B) Time lapse images of single cells (small arrows) breaking off from a developing Oct-4 GFP+ colony (large yellow arrow). These single cells established smaller colonies in the vicinity of the main colony. We termed the smaller colonies “satellite” colonies. Time stamp in hour:minute format. All bars = 100 μm.