Table 2. EatA sequence conservation in geographically, temporally, and phylogenically disparate isolates.

strain	accession	origin	isolation reported	phenotype	identity1 (%)	Similarity (%)	ref.
H10407	Q84GK0.1	Bangladesh	1973	cholera-like	-	-	[52]
Throop D	2 EMW91712.1	Dallas, TX	1976	cholera-like	98	99	[36]
Envira 10/1	2 EMX71514.1	Amazon, Brazil	1998	cholera-like	97	98	[35]
Juruá 18/11	2 EMX58104.1	Amazon, Brazil	1998	cholera-like	96	98	[35]
2850750	2 EMW01116.1	Bangladesh	2008	cholera-like	96	97	5
2871950	2 EMV49671.1	Bangladesh	2008	cholera-like	96	98	5
P0305293.1	2 EMZ82436.1	Bangladesh	2011	cholera-like	97	98	5
P0304777.1	2 EMX02137.1	Bangladesh	2011	cholera-like	96	97	5
2720900	2 EMX91421.1	Bangladesh	2007	cholera-like	100	100	5
178900	2 ENA71292.1	Bangladesh	2010	cholera-like	98	99	5
180200	2 ENA61350.1	Bangladesh	2010	cholera-like	96	98	5
2722950	2 EMZ73955.1	Bangladesh	2007	mild-self-limited	98	99	5
tw10598	3 AELA00000000.1	Guinea-Bissau	1996	diarrhea4	96	98	[49]
tw10722	3 AELB00000000.1	Guinea-Bissau	1996	diarrhea4	95	98	[49]
tw10828	3 AELC00000000.1	Guinea-Bissau	1996	diarrhea4	95	97	[49]
tw11681	3 AELD00000000.1	Guinea-Bissau	1996	diarrhea4	98	99	[49]
B2C	ETS27975.1	Vietnam	1971	diarrhea4	96	98	[62]
E24377A	YP_001451588.1	Egypt	1980s	diarrhea4	96	97	[63]

¹based on BLAST-P searches against 1042 residues of predicted passenger domain of H10407.

²sequenced at GSCID (http://gscid.igs.umaryland.edu/wp.php?wp=comparative_genome_analysis_of_enterotoxigenic_e._coli_isolates_from_infections_of_different_clinical_severity)

³open reading frames corresponding to the eatA gene were first assembled from whole genome shotgun sequence contigs for these draft genomes; BLASTP for these homologues was conducted using CLC Main Workbench v6.9.1 and local database of predicted protein sequences derived from translation of assembled contigs from the respective sequencing projects.

⁴(severity unknown)

⁵this study