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. 2015 Jan 28;10(1):e0113705. doi: 10.1371/journal.pone.0113705

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© 2015 Fjellström et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 17 — ^alogD measured by liquid chromatography. ^bCaco2 A to B permeability measured at pH 6.5. ^cEfflux ratio determined in Caco2 cells by dividing P_app B to A with P_app A to B permeabilities measured at pH 7.4 at side A. ^dRat intrinsic clearance determined from measurements in rat hepatocytes. ^eRat in vivo clearance. ^fCaco2 A to B permeability measured at pH 7.4 at side A.