Table 1. Characteristics of the study subjects.

Cohort		Discovery	Replication
N° of Individuals		1054	535
Women %		56.5	54.2
Age (mean ± SD)		52.4 ± 19.8	52.9 ± 19.5
Genealogical Kinship (mean ± SD)		0.0032±0.0156	0.0083±0.0214
CRIPTO (pg/ml)
All	median	27.5	184.4
	95% CI	21.3–34.3	133.2–211.7
	Range	0–1514.3	0–1253.2
Men	median	25.9	168.4
	95% CI	17.6–42.7	71.6–217.2
	Range	0–1514.3	0–1253.2
Women	median	29.0	188.9
	95% CI	19.6–35.6	117.7–221.4
	Range	0–1428.9	0–1174.2