Table 2.
Phenoconverting inhibitor | Substrate | Ratio of substrate AUC with and without inhibitor |
---|---|---|
Quinidine | Mexiletine | 1.32 |
Imipramine | 1.54 | |
Propafenone | 2.70 | |
Propranolol | 1.98–3.00 | |
Metoprolol | 3.24 | |
Desipramine | 7.50 | |
Encainide | 11.40 | |
Dextromethorphan | 13–49 (depending on the dose of quinidine) | |
Fluoxetine | Propafenone | 1.50 |
(R)-Carvedilol | 1.77 | |
Imipramine | 3.33 | |
Desipramine | 4.80 | |
Tolterodine | 4.84 | |
Paroxetine | Tamsulosin | 1.64 |
Imipramine | 1.74 | |
Aripiprazole | 2.36 | |
(R,S)-Metoprolol | 4.21–6.16 | |
(S)-Metoprolol | 5.08 | |
Desipramine | 4.64–5.21 | |
Atomoxetine | 6.50 | |
Perphenazine | 6.96 | |
(R)-Metoprolol | 7.93 | |
Terbinafine | Paroxetine | 2.50 |
Desipramine | 4.94 | |
Cinacalcet | Desipramine | 3.6 |
Dextromethorphan | 11.5 |
Abbreviation is as follows: AUC, area under the plasma concentration vs. time curve. [Compiled from literature review.]