Figure 6.

Simulations of three adalimumab dosing regimens using typical pharmacokinetic and PK–PD parameters: no loading dose (40 mg every other week); 80 mg loading dose (80 mg, then 40 mg every other week); and 160 mg loading dose (160 mg, then 40 mg every other week). Using a 160 mg loading dose, adalimumab concentrations after the loading dose are superior to steady-state concentrations, and maximal effect is reached between the first and the second injections. —, no loading dose; —, 80 mg loading dose; —, 160 mg loading dose