Table 1.
Patient demographic and overdose information
| Median (range) | Number of patients (%) | |
|---|---|---|
| Age (years) | 32 (15–55) | 28 (100) |
| Male | 7 (25) | |
| Prescribed therapeutic dose (mg) for patients on sertraline prior to the overdose event | 100 (25–200) | 24 (86) |
| Overdose reported (mg) | 1550 (250–5000) | 28 (100) |
| Co-ingested medications/substances: | ||
| Alcohol | 10 (36) | |
| Analgesics (paracetamol, codeine, ibuprofen) | 6 (21) | |
| Anticoagulants (warfarin) | 1 (4) | |
| Antiepileptics (sodium valproate) | 1 (4) | |
| Antihistamines (dexchlorpheniramine, doxylamine) | 3 (11) | |
| Antihypertensives (atenolol, candesartan) | 2 (7) | |
| Antipsychotics (olanzapine, quetiapine, risperidone) | 3 (11) | |
| Benzodiazepines | 4 (14) | |
| Decongestants (phenylephrine, pseudoephedrine) | 2 (7) | |
| Herbal preparations (valerian) | 1 (4) | |
| Unknown substances | 1 (4) | |
| Nil | 9 (32) | |
| Measured sertraline concentration range (mg l−1) | 0.016–0.896 | |
| Veracity score | ||
| 1 | 14 (50) | |
| 2 | 11 (39) | |
| 3 | 3 (11) | |
| 4 | 0 (0) | |
| Single dose activated charcoal (SDAC) | 7 (25)* | |
| Median overdose in patients treated with SDAC (mg) | 1900(250–2800) | |
| Median overdose in patients not treated with SDAC (mg) | 1500 (300–5000) |
*
One patient received a partial dose of SDAC of approximately 12.5 g.