Table 4.
Comparative Survival Analyses of GIST Patients With and Without Secondary Malignancies
| (Ntotal= 267/569) |
With 2nd NPL |
Without 2nd NPL |
Univariate Cox model |
Multivariate Cox model |
||
|---|---|---|---|---|---|---|
| % | (N) | % | (N) | P, HR (95% CI) | P, HR (95% CI) | |
| Disease-specific-survival | ||||||
| 1-year DSS | 99.0 | (194) | 96.6 | (435) | P = .603, HR 1.164 (0.657;2.061) | P = .880, HR 1.053 (0.536;2.070) |
| 3-year DSS | 96.5 | (135) | 93.4 | (319) | ||
| 5-year DSS | 90.8 | (88) | 90.9 | (212) | ||
| Overall-survival | ||||||
| 1-year OS | 88.5 | (194) | 94.0 | (435) | P < .001 HR 0.397 (0.298;0.530) | P < .001 HR 0.402 (0.282;0.575) |
| 3-year OS | 75.0 | (135) | 88.3 | (319) | ||
| 5-year OS | 62.8 | (88) | 83.4 | (212) | ||
| Disease-free survival | ||||||
| 1-year DFS | 90.7 | (159) | 88.1 | (367) | P = .586 HR 1.118 (0.748;1.672) | P = .616 HR 0.883 (0.544;1.435) |
| 3-year DFS | 88.1 | (108) | 83.4 | (258) | ||
| 5-year DFS | 82.7 | (66) | 81.5 | (173) | ||
DSS, disease specific survival; DSF, disease free survival; OS, overall survival; HR, hazard ratio.
Multivariate Cox proportional hazards regression model has been adjusted considering the variables age, gender, mitotic rate, tumor size and localization (GIST).