Skip to main content
. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Biol Psychiatry. 2014 Jul 28;79(5):362–371. doi: 10.1016/j.biopsych.2014.07.019

Figure 5. Effects of doxycycline (Dox) inducible overexpression of ΔFosB or ΔcJun on L-DOPA-induced dyskinesia.

Figure 5

Mice that inducibly overexpress ΔFosB (A, B, Off Dox) or ΔcJun (C, D, Off Dox) and control littermates (A–D, On Dox) were lesioned with 6-OHDA and treated for 14 days with 20 mg/kg of L-DOPA (in combination with 12.5 mg/kg of benserazide). A, C, Time profile of total abnormal involuntary movements (AIMs) in mice scored for 1 min every 20 min over a period of 2 hr after the last administration of L-DOPA. Repeated measures ANOVA revealed a significant effect of genotype for mice overexpressing ΔFosB and ΔcJun (p < 0.05 vs. respective control On Dox littermates). B, Sum of total abnormal involuntary movements (AIMs) scored for a period of 2 hr immediately following the last administration of L-DOPA. * p < 0.05 vs. control (On Dox) littermates for the FosB group and for the ΔcJun group. Data are shown as means ± SEM.

HHS Vulnerability Disclosure