Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
PACAP increases cystine uptake through system xc− in a concentration-dependent manner. (A) Concentration response of 24-hour PACAP treatment on primary mixed cortical cultures on radiolabeled cystine uptake (n = 6–12). (B) Inhibition of system xc− with (S)-4-carboxyphenylglycine (CPG; 200 µM) blocks cystine uptake in both control and PACAP (1 nM) treated primary mixed cortical cultures (n = 4–12). Data are expressed as mean ± SEM. * = P < 0.05 compared to control group.
