Table 2.
Univariate and multivariate analyses of associations between clinicopathological factors and overall survival in patients who underwent simultaneous resection for synchronous colorectal liver metastases
| Prognostic factor | Univariate analysis
|
Multivariate analysis
|
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (>60:≤60) | 0.623 | 0.320–1.214 | 0.165 | |||
| Sex (female:male) | 1.620 | 0.890–2.949 | 0.115 | |||
| Primary tumor site (rectum:colon) | 1.314 | 0.706–2.443 | 0.389 | |||
| Histological type (mucinous adenocarcinoma: adenocarcinoma) | 0.795 | 0.313–2.023 | 0.631 | |||
| Tumor differentiation (well, moderate: poor and others) | 1.564 | 0.850–2.880 | 0.151 | |||
| Primary tumor (T) stage (T3, T4:T1, T2) | 2.585 | 0.355–18.803 | 0.348 | |||
| Primary nodal (N) stage (N1, N2:N0) | 3.304 | 1.530–7.132 | 0.002 | 4.200 | 1.912–9.224 | <0.001 |
| Vascular invasion (positive:negative) | 2.616 | 1.308–5.230 | 0.007 | 3.561 | 1.688–7.514 | 0.001 |
| Nerve invasion (positive:negative) | 2.569 | 1.068–6.177 | 0.035 | 1.622 | 0.651–4.042 | 0.299 |
| No of liver metastases (≥4: ≤3) | 1.485 | 0.984–5.643 | 0.022 | 3.408 | 1.478–7.859 | 0.004 |
| Size of liver metastases (≥5 cm:<5 cm) | 2.589 | 1.145–5.854 | 0.237 | |||
| Extrahepatic metastases resection (yes:no) | 2.198 | 0.677–7.134 | 0.190 | |||
| CEA (.5 ng/mL:>5 ng/mL) | 1.824 | 0.896–3.715 | 0.098 | 1.647 | 0.805–3.368 | 0.172 |
| Chemotherapy (postoperative:perioperative) | 1.077 | 0.561–2.069 | 0.824 | |||
| Tumor deposits (positive:negative) | 1.859 | 1.019–3.389 | 0.043 | 1.541 | 0.820–2.895 | 0.179 |
Abbreviations: HR, hazard ratio; CI, confidence interval.