Table II.
Candesartan Cilexetil (CC) Encapsulation Efficiency and Weight Fraction in Niosomes (Mean ± Standard Error)
| Formulation code | Surfactant | HLB | Charging agent | Encapsulation efficiency (%) | Weight of loaded drug (%) |
|---|---|---|---|---|---|
| F1 | Span 60 | 4.7 | DCP | 94.99 ± 0.76 | 39.55 ± 0.19 |
| F2 | Span 60, Pluronic L64 | 13.7 | DCP | 73.21 ± 2.93 | 19.65 ± 1.60 |
| F3 | Pluronic L64 | 15 | DCP | 36.26 ± 2.78 | 11.79 ± 0.42 |
| F4 | Span 60, Pluronic F127 | 21.4 | DCP | 66.48 ± 3.34 | 4.56 ± 1.25 |
| F5 | Pluronic F127 | 22 | DCP | 92.32 ± 1.07 | 1.67 ± 0.13 |
| F6 | Pluronic P85 | 16 | DCP | 80.11 ± 2.42 | 6.27 ± 1.20 |
| F7 | Span 60, Pluronic P85 | 15 | DCP | 99.06 ± 1.74 | 13.42 ± 1.40 |
| F8 | Span 60, Pluronic P85 | 15 | DCP | 62.73 ± 4.58 | 13.62 ± 1.42 |
| F9 | Span 60, Pluronic P85 | 15 | SA | 59.82 ± 1.89 | 15.75 ± 0.52 |
| F10 | Span 60, Pluronic P85 | 15 | SA | ND | ND |
HLB hydrophilic-lipophilic balance, DCP dicetyl phosphate, SA stearylamine, ND not determined