Fig. 8.

The percentage of multiplets (on the left y-axis) with the ratio of residual drug MMAD to the MMAD of the micronized drug (on the right y-axis) for a given number of particles per unit volume (PPUV). The various symbols refer to different micronized drug size (all with GSD of 1.8). Unshaded symbols correspond to the percentage of multiplets axis. Shaded symbols correspond to the MMAD ratio. All simulated formulations contained drug concentration between 0.1 and 1.2% (w/w), 8% ethanol in HFA-134a, with no additional excipients