Table III.

Mean Observed and Predicted AUC_{0–120 h} and C _max for 120 mg Etoricoxib Tablets for Three Clinical Studies

Clinical study	AUC0–120 h (μg*h/mL)			C max (μg/mL)
	Observed	Predicted	% PE	Observed	Predicted	% PE
Protocol 43	39.5	35.8	−9.4	1.88	1.83	−2.7
Protocol 48	36.7		−2.5	2.27		−19.4
Protocol 70	32.9 (MR-4312)		8.8	1.74 (MR-4312)		5.2
	33.5 (MR-4629)		6.9	1.72 (MR-4629)		6.4

For protocol number 70, predicted and observed data for two different tablet batches MR-4312 and MR-4619 are shown. The % prediction errors (% PE) for these simulations were calculated as ((predicted–observed)/observed) × 100. All the observed clinical data are on Merck file

AUC area under curve, C _max maximum plasma concentration