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Input Data Used for the Simulations
| Drug | Glyburide | Montelukast |
|---|---|---|
| Dose (mg) | 3.5 (15) | 10 (14) |
| Dosage form | Immediate release (15) | Immediate release (14) |
| Solubility (mg/mL) | 0.043 at pH 7.4 (15) | 0.0007 at pH 6.5 (16) |
| Mean particle radius (μm) | 6.28 (15) | 6.572 (14) |
| Particle density (g/mL) | 1.38 (15) | 1.2 (ADMET 5 default setting) |
| Diffusion coefficient (cm2/s × 10−5) | 0.5878 (15) | 0.54 (ADMET 5) |
| pKa | 5.5, (ADMET 5) 11.62,10.64 | 2.8, 5.7 (16) |
