Table 2.
Results of multiple linear regression models exploring the effect of childhood adversity and an apolipoprotein-ε4 (APOE-ε4) carrier status on depressive symptoms
| B (95% CI) | SE | t | p | |
|---|---|---|---|---|
| Model 1: Overall | ||||
| Intercept | −0.04 (−11.01, 10.92) | 5.54 | −0.01 | 0.994 |
| ACE scores | 0.54 (0.20, 0.88) | 0.17 | 3.14 | 0.002 |
| APOE-ε4 carrier status (for ACE=0) | 1.55 (−0.54, 3.64) | 1.06 | 1.46 | 0.145 |
| Model 2 | ||||
| Non-carrier | ||||
| Intercept | 1.37 (−9.50, 12.23) | 5.49 | 0.25 | 0.804 |
| ACE scores | 0.32 (−0.07, 0.71) | 0.20 | 1.63 | 0.107 |
| Carrier | ||||
| Intercept | 1.56 (−9.42, 12.54) | 5.55 | 0.28 | 0.779 |
| ACE scores | 1.17 (0.52, 1.82) | 0.33 | 3.56 | 0.001 |
| APOE-ε4 carrier status (for ACE=0) | 0.19 (−2.19, 2.58) | 1.21 | 0.16 | 0.874 |
| ACE×APOE-ε4 | 0.85 (0.10, 1.61) | 0.38 | 2.24 | 0.027 |
B=unstandardized regression coefficient; CI=confidence interval; SE=standard error; ACE=adverse childhood experiences.
Independent variables are displayed in the first column and the dependent variables are the Quick Inventory of Depressive Symptomatology-Self Rating (QIDS-SR) scores. Model 1 includes sex, age, educational years, marital and occupational status, ACE scores, and APOE-ε4 carrier status as independent variables; Model 2 includes an ACE×APOE-ε4 interaction term in addition to the variables in model 1. The intercept is the value when all the adjustment variables have a value of 0 (i.e., sex=male, age=0 year, educational years=0, marital status=married, occupational status=employed).
F=7.50, p<0.001, and R2=0.28 in Model 1, and F=7.43, p<0.001, and R2=0.30 in Model 2.
The proportions of floor and ceiling values were 58.4 and 0% for ACE and 3.6 and 0% for QIDS-SR.