Table 3.
Association of urinary 8-oxodG and 8-oxoGuo with overall cancer risk.
| Outcome |
Model 1 HR (95% CI) |
p Value |
Model 2 HR (95% CI) |
p Value |
Model 3 HR (95% CI) |
p Value |
|---|---|---|---|---|---|---|
| Any cancer (n=264) | ||||||
| 8-oxodG | 0.25⁎ | 0.74⁎ | 0.98⁎ | |||
| 1st quartile | 1.00 | 1.00 | 1.00 | |||
| 2nd quartile | 0.92 (0.63–1.32) | 0.63 | 0.85 (0.59–1.24) | 0.40 | 0.85 (0.58–1.24) | 0.40 |
| 3rd quartile | 0.97 (0.69–1.36) | 0.87 | 0.88 (0.62–1.25) | 0.48 | 0.88 (0.62–1.25) | 0.46 |
| 4th quartile | 1.22 (0.85–1.74) | 0.27 | 1.05 (0.73–1.52) | 0.79 | 1.00 (0.69–1.46) | 0.99 |
| Log 8-oxodG | 1.13 (0.82–1.54) | 0.46 | 1.00 (0.72–1.38) | 0.99 | 0.94 (0.68–1.29) | 0.68 |
| 8-oxoGuo | 0.06⁎ | 0.64⁎ | 0.91⁎ | |||
| 1st quartile | 1.00 | 1.00 | 1.00 | |||
| 2nd quartile | 1.15 (0.82–1.61) | 0.41 | 1.07 (0.76–1.50) | 0.72 | 0.97 (0.68–1.37) | 0.85 |
| 3rd quartile | 1.25 (0.90–1.74) | 0.18 | 1.00 (0.70–1.43) | 0.99 | 0.96 (0.67–1.37) | 0.82 |
| 4th quartile | 1.39 (0.98–1.98) | 0.07 | 1.13 (0.77–1.64) | 0.53 | 0.98 (0.67–1.44) | 0.92 |
| Log 8-oxoGuo | 1.35 (1.01–1.81) | 0.04 | 1.08 (0.79–1.49) | 0.63 | 0.98 (0.71–1.37) | 0.93 |
Model 1: unadjusted model. Model 2: adjusted for age and sex. Model 3: adjusted for sex, age, smoking status, physical activity, education, BMI, alcohol consumption and cohabitation status.
⁎
p Value for linear trend across quartiles.