Table 1.

Functional protein–protein interaction clusters of oxoLPP-modified proteins, identified in untreated cells and cells treated with FA, CoCl₂ and a combination of both, assigned by STRING analysis and manual annotation. Cluster numbers corresponds to the one provided in Figs. 6 and S2–S4. Number of proteins involved in a cluster shown in [brackets]. PM—plasma membrane; C—cytoskeleton; ECM—extracellular matrix.

Control	FA	CoCl2	FA/CoCl2
I. Cytoskeleton–plasma membrane–ECM (C–PM–ECM)
	1. C–PM–ECM architecture [16]	1. C–PM architecture [7]	2. C–PM architecture [7]
	2. PM associated ATPases [7]	2. C–PM architecture [11]
	3. C–PM receptors signaling [7]
	4. C–PM signaling [10]
II. Plasma membrane and secreted proteins
		5. PM and secreted proteins [5]	3. PM and secreted proteins [14]
			4. Proteoglycan synthesis [3]
III. Cytoskeleton related transport and motility
		7. Cytoskeletal transport [8]	9. Dynein related motility [3]
		8. Cytoskeletal transport [6]
IV. Nuclear pore organization
	5. Nuclear pore and transport [3]
V. Cytoskeletal proteins involved in cell division
	6. Cell division, chromosome segregation [17]
	7. Centrosome organization [5]
VI. Signaling
3. Cytoskeleton mediated signaling [6]		3. Inositol-phosphate related [3]	1. PM-cytoskeleton signal transduction [18]
		#4. Signaling [3]
VII. Regulation of transcription
	12. NFκB related transcription [5]
	13. Regulation of transcription [13]
VIII. Chromatin remodeling
1. Chromatin remodeling [4]			6. Chromatin remodeling and DNA replication [15]
IX. Splicing
	8. Regulation of transcription and splicing [12]	6. Splicing [3]	7. Splicing [7]
X. Protein synthesis and degradation
	9. Ribosome biogenesis and regulation [16]
	10. Protein synthesis and folding [9]		5. Protein synthesis and folding [7]
2. Proteosome [3]
XI. DNA repair
	11. DNA repair [9]
XII. Regulation of lipid metabolism
	14. Regulation of lipid metabolism [5]		8. Regulation of lipid metabolism [5]