Table 2.

Characteristics of pain (PSS; pain related interference with daily activities) as reported in patients with ALS and age- and gender-matched population-based controls. Data are given either as percentages or median (range). ^*Differences between groups were analyzed using Kruskal–Wallis One Way Analysis of Variance on Ranks, post hoc analysis was carried out using all pairwise multiple comparison procedures (Holm–Sidak method)

	ALS	DM2	Controls	P
Men/women (%)	20/26	19/4	20/26
Mean age (years)	64.0±10.8 (31–79)	60±10.7 (27–77)	60.0±10.1 (39–77)	n.s.*,a
Reporting pain (Number (%) out of total population)	36 (78)	19 (83)	25 (54)
Pain severity (0–10)
Median PSS (range)	3.0 (0.5–6.8)	2.8 (0–6.0)	2.0 (0.5–5.3)	n.s.*,a
PSS subgroups
No pain (rating of 0) [n (%)]	–	–	–
Mild pain (1–3) [n (%)]	21 (58)	9 (47)	20 (80)
Moderate pain (4–6) [n (%)]	14 (39)	10 (53)	5 (20)
Severe pain (7–10) [n (%)]	1 (3)	0 (0)	0 (0)
Pain related interference with daily activities (0–10)
Median pain interference score (range)	3.0 (0.75–6.75)	3.4 (0–6.6)	1.2 (0.75–5.25)	<0.05*,b
General activity, median (range)	3.0 (0–10)	4.2 (0–10)	2.0 (0–5)	<0.05*,c
Mood, median (range)	4.0 (0–10)	3.1 (0–10)	1.0 (0–5)	<0.01*,b
Walking ability, median (range)	3.0 (0–10)	4.2 (0–9)	1.0 (0–7)	<0.05*,b
Normal work, median (range)	2.5 (0–10)	4.7 (0–10)	1.0 (0–8)	<0.05*,b
Relations with other people, median (range)	1.5 (0–10)	1.6 (0–5)	0 (0–3)	<0.05*,b
Sleep, median (range)	3.0 (0–9)	3.6 (0–10)	2.0 (0–9)	n.s.*,a
Enjoyment of life, median (range)	5.0 (0–10)	2.9 (0–9)	1.0 (0–6)	<0.01*,b
Treatment for pain n (%)	17 (47)	9 (47)	11 (43)

ALS amyotrophic lateral sclerosis, DM2 myotonic dystrophy type 2, PSS pain severity score.

^*Post hoc analysis using all pairwise multiple comparison procedures (Holm–Sidak method or Dunn's method):

^ano difference between groups,

^bP < 0.05 ALS and DM2 versus controls,

^cP < 0.05 DM2 versus controls.